Hereditary breast and ovarian cancer (HBOC) syndrome is a relatively new condition in research terms.  Despite being first discovered 25 years ago, the landscape is still changing and will continue to do so in the future. For many years, BR(reast)CA(ancer) gene mutations were the only known cause of HBOC syndrome. This is why most of the research and resources focus so much on BRCA1 and BRCA2.  Since then, several related types of cancer were discovered along with additional genes.  Below is a list of risky genes based on the comprehensive gene panel used by Color Genomics and a link to Myriad Lab's MySupport360, where you can learn more about these and other hereditary cancer genes.


More about genetic testing.


Important: Those who received a negative result after being tested for BRCA-only gene mutations in the past may want to consider being re-tested with a more comprehensive gene panel.  ANCESTRY DNA sites are NOT COMPREHENSIVE.  As an example, My23andMe searches for only three mutations typical within the Ashkenazi Jewish population out of thousands of possible BRCA and other risky gene mutations.   

List of Risky Genes