Hereditary breast cancer was first discovered in the mid 1990's with mutations in the BRCA1 and BRCA2 genes, which are responsible for tumor-suppression in certain parts of the body. Harmful mutations of these genes disable the tumor-suppressing proteins and put the carrier at risk for developing certain cancers. Today, researchers know mutations in these and other genes also cause ovarian, prostate and some other types of cancer. We often refer to HBOC syndrome as 'risky genes' to be more inclusive to men and the other types of cancer involved.
Every person carries HBOC syndrome genes, whether male or female, and both sexes can pass mutations in those genes to their biological children at a rate of 50%.
Average hereditary prostate cancer risk is not as high as hereditary breast or ovarian cancer but is still considerably higher than in the general population. Hereditary prostate cancer risk is often displayed in average ranges and varies, depending on the source. Personal cancer risk must be assessed by a professional and is based on which gene is mutated, the type of mutation within that gene and a variety of other factors, including number of first-degree relatives with relevant types of cancer.
Although hereditary prostate cancer has been known to those involved with HBOC syndrome for some time, it was only recently recognized with with the AUA consensus statement regarding hereditary prostate cancer risk.
Hereditary prostate cancers tend to be more aggressive, so treatment may vary from those for the general population. For example, The Journal of Clinical Oncology recommends immediate surgery of BRCA2 genetic prostate cancer.
To have evidence for prostate cancer risk and access to early prostate cancer screening
To have evidence for male breast, pancreas, melanoma and other related cancer risk and access to cancer screening LEARN MORE
To have knowledge of increased cancer risk for children and other biological family members so they have the opportunity to make informed health decisions LEARN MORE
If a partner is also a carrier, to have knowledge about increased risks to biological children for other health issues so decisions can be made that may include pre-implantation diagnosis. For example, a union between a BRCA2 carrier and another BRCA2 carrier may result in Fanconi Anemia LEARN MORE
In the event of an hereditary cancer diagnosis, knowledge of an inherited mutation may alter the type of cancer treatment LEARN MORE
No fee genetic testing is available through government health services but is dependent on certain criteria. Anyone can obtain genetic testing through certain private clinics and through affordable online services LEARN MORE
Hereditary Prostate Cancer
The American Urological Association has recognized the importance of genetic testing with regard to inherited prostate cancer and the need for early screening. LEARN MORE