For many years, BR(reast)CA(ncer)1 and BRCA2 were thought to be the only genes that, if mutated, were responsible for HBOC syndrome. Scientists have now discovered over 18 other genes also responsible.  With only a portion of hereditary cancer discovered to date, risky genes will be continue to be discovered.  This means, those who in the past received a negative result for BRCA gene mutations may want to consider being re-tested with a more comprehensive gene panel.  In addition, those returning a negative result with today's gene panels may want to revisit genetic testing in the future as more risky genes are added. 


Canadian docs discover new gene mutation linked to breast cancer risk

In Canada, government-insured genetic testing is only available under certain circumstances and, even if one does qualify, it may mean long wait times. As an alternative, Color Genomics, is a highly reputable service with a quick-turnaround, comprehensive gene-panel saliva test. The test must be ordered by a doctor.  If your own doctor is not willing, Color can provide a doctor to facilitate the order. 


Genetic counselling is included in the cost, which ranges from $50US if your family already has an identified mutation, to $249US for a comprehensive gene panel that includes all known HBOC syndrome genes.  This test also looks for a variety of additional conditions, so if you do not want that information be sure to mention that when ordering. 


types of genetic tests

Genetic testing is available for persons 18+ years of age and consist of a blood or saliva test.  Although genetic testing is available at age 18, in most cases,  screening and prevention options are not recommended until the age of 25.  


Government-insured genetic testing and follow-up counselling cost nothing for those who already have an identified risky gene mutation in their family, satisfy government family cancer history criteria or have been diagnosed with a suspect cancer.


Wait times for genetic test results vary from a matter of weeks up to many months, depending on the provider and type of service used. Most government-insured services tend to have longer wait times than pay services.


If you do not qualify for government-insured genetic testing or are not comfortable with the wait times in your region, there are private clinic and online alternatives but make sure you choose a reputable service. 




In March 2017, a Bill was passed that protects individual's genetic information.  However, at the time of the last website update, it had still not been put into law.  Ensure all life and disability insurance is in place prior to considering genetic testing.  


Bill S-201: Government Seeking Supreme Court's Advice On Genetic Discrimination Bill


Lift Insurance News - Understanding Genetic Testing and Life Insurance


The wait leading up to genetic testing and for results can be very stressful.  Make sure you are supported before, during and after this process.  If you don't have anyone who can do this for you, contact us and we will put you in touch with someone who has been there.


There are many things to think about prior to and after genetic testing.  Here are someimportant considerations.



HBOC syndrome is complicated and not well-understood, even by our medical professionals, so consumers should be well-educated to choose the best fit for them.  The first thing to be aware of is that not all genetic tests are created equal.  The type of test needed is dependent on the circumstances and on how comprehensive you wish the test to be.  Do you want to be tested for all HBOC syndrome risky genes that have been discovered to date?  Has a mutation already been identified in your family?  Are you of Ashkenazi Jewish decent or of one of the other ethnic groups that experiences a higher rate of HBOC syndrome? 


Multi-gene panel tests
Panel tests look for mutations across several genes at the same time, giving you a good snapshot of your broader risk for various cancers and health conditions.  It is important to know that the multi-gene panel test may identify other cancer risks that weren’t previously on your radar.  So, if you don't want that information, that must be conveyed. 

Single-gene tests
Historically, genetic testing has focused on examining one gene at a time.  If your first single-gene test didn’t find a mutation, your healthcare provider or genetic counsellor may order follow-up tests for a different gene (or genes). With the advent of multi-gene panels this process is becoming less frequent.

Single-site tests
If you have a family history of a mutation in one gene, a single-site test may be the best option for you. This type of test looks for the specific mutation that’s already been identified. Because it’s only looking for one mutation, this test may be less expensive and results may come quicker.

If you are of Ashkenazi Jewish ancestry, a single-site test for the three common founder BRCA1/2 mutations may be especially helpful.

Getting the Right Test
Work closely with your healthcare provider or a genetic counsellor to understand which test is best, given your situation.  If you’re uncomfortable with the type of test being suggested to you, keep asking questions and expressing your concerns until you feel satisfied or contact us for more information.  Over 1,200 mutations have been discovered to date in each of the BRCA genes alone.  Some of these mutations do not increase cancer risk.  In all cases, it is essential a genetics professional interpret the results.


Misunderstood Gene Tests May Lead to Unnecessary Mastectomies


23andMe released the first consumer-direct BRCA test kit that doesn't require a doctor to facilitate the order.  It’s important to note the three mutations that can be picked up by the at-home test are just a small fraction of the known BRCA mutations associated with an increased risk for cancer. Over 5,000 different mutations have been discovered to date in just BRCA1 and BRCA2 alone.  So although this test may be somewhat useful for people of Ashkenazi Jewish heritage or those who are interested in these particular mutations, it won’t pick up on most BRCA genetic mutations that would increase your risk of breast cancer. Therefore, any result you get from the test—negative or positive—is only a small window into your total genetic cancer risk.

Genetic experts have a message for anyone thinking of taking 23andMe's new breast cancer test

Personal genetic information is not yet protected in some regionsEnsure life and disability insurance is in place prior to considering genetic testing

Ensure the test you choose includes a genetic counselling session by a professional. 
DO NOT let your doctor interpret the results


If you do not fit the criteria for government-insured genetic testing, there are affordable, no-barrier options available available through a private clinic or online These must be ordered by a doctor.


Do your homework to ensure you have chosen the genetic test right for you


TESTING in those with ovarian cancer

TYPES OF GENETIC TESTS

general POPULATION TESTING



OnlineProponents of widespread testing, also known as population testing, believe current guidelines ignore the fact that the genetic predisposition to cancer can be hidden in families. This is because an inherited mutation can be passed down not only by females, but also by males who tend to present with less cancer than females. For this reason, reliance on family medical history may not be enough.


 Dr. Mary-Claire King, who first discovered hereditary breast cancer, believes that too many carriers are being missed due to the restrictive criteria for insurance-paid services. This has basis in an increasing body of evidence.  Dr. King’s own research reported about 50% of the study group who were diagnosed with breast cancer and were BRCA positive did not have a close family history of cancer.  Dr. Steven Narod, world leader in hereditary breast cancer genetics, and his team have tested thousands of women in Ontario, most who do not have a family connection to breast or ovarian cancer. His research has shown that fewer than half of the Jewish women that have been found to carry BRCA mutations would not have qualified for government-insured genetic testing. 


Dr. King serves as an unpaid scientific advisor to Color Genomics, an affordable, no-barrier, full-gene-panel service now available in Canada that includes genetic counselling.  If you would like to learn more, contact us.


BRCA Testing Has Skyrocketed, but Misses High-Risk Women


Study says all Ashkenazi women should be tested for cancer gene


Genetic mutation missed in about half of Ashkenazi  Jewish women


Online genetic test gives woman falso hope of cancer-free life

Genetic Testing

As researchers learn more, the percentage of ovarian cancer known to be hereditary is steadily growing.  Although not yet a medical recommendation in most regions, many medical professionals suggest that anyone with an ovarian cancer diagnoses receive genetic testing.  This is because it may change the treatment course and other family members will need the information to make decisions about their health.  Recently, new chemotherapy drugs have been approved or are in clinical trial that are specifically designed for hereditary ovarian cancer.


Why Genetic Testing Is So Important in Ovarian Cancer

New treatment option for ovarian cancer: PARP inhibitors

INSURANCE